Similarly, although a null effect was not excluded, advantageous effects of low dose steroids had a high probability of dependence upon patient underlying risk.
Low dose steroid efficacy was not demonstrated in corticotrophin non-responders.
Sepsis may be complicated by impaired corticosteroid metabolism.
During past decades, many strategies have been implemented with the aim of optimizing the outcome of patients with severe lung infections.
State of immunocompromisation during severe pneumonia related to multiple drug-resistant infections which may contribute to severe hypoxemic respiratory failure triggering septic shock and fatal outcome associated with multiple organ dysfunction syndromes.
RESULTS Corticosteroid efficacy, compared with control, for hospital-mortality, proportion of patients experiencing shock-resolution, and infective and non-infective complications was assessed using Bayesian random-effects models; expressed as odds ratio (OR, (95% credible-interval)).
Low-dose trials ( Although a null effect for mortality treatment efficacy of low dose corticosteroid therapy in severe sepsis and septic shock was not excluded, there remained a high probability of treatment efficacy, more so with outlier exclusion.